The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

Jae Ho Seo; Dayana B. Rivadeneira; M. Cecilia Caino; Young Chan Chae; David W. Speicher; Hsin-Yao Tang; Valentina Vaira; Silvano Bosari; Alessandro Palleschi; Paolo Rampini; Andrew V. Kossenkov; Lucia R. Languino; Dario C. Altieri

doi:10.1371/journal.pbio.1002507

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Open Access

Peer-reviewed

Research Article

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

Jae Ho Seo,

Affiliations Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Dayana B. Rivadeneira,

Affiliations Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
M. Cecilia Caino,

Affiliations Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Young Chan Chae,

Affiliations Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
David W. Speicher,

Affiliations Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Hsin-Yao Tang,

Affiliation Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0003-1838-018X

⨯
Valentina Vaira,

Affiliations Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
⨯
Silvano Bosari,

Affiliations Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
⨯
Alessandro Palleschi,

Affiliation Division of Thoracic Surgery, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

http://orcid.org/0000-0003-4510-5167

⨯
Paolo Rampini,

Affiliation Division of Neurosurgery, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Andrew V. Kossenkov,

Affiliation Center for Systems and Computational Biology, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Lucia R. Languino,

Affiliations Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Dario C. Altieri

* E-mail: daltieri@wistar.org

Affiliations Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America, Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

Jae Ho Seo,
Dayana B. Rivadeneira,
M. Cecilia Caino,
Young Chan Chae,
David W. Speicher,
Hsin-Yao Tang,
Valentina Vaira,
Silvano Bosari,
Alessandro Palleschi,
Paolo Rampini

Published: July 7, 2016
https://doi.org/10.1371/journal.pbio.1002507

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