Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase

Shuangxi Li; Shuang Li; Yuhong Han; Chao Tong; Bing Wang; Yongbin Chen; Jin Jiang

doi:10.1371/journal.pbio.1002481

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Peer-reviewed

Research Article

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase

Shuangxi Li ,

Contributed equally to this work with: Shuangxi Li, Shuang Li

Affiliations Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
⨯
Shuang Li ,

Contributed equally to this work with: Shuangxi Li, Shuang Li

Affiliations Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
⨯
Yuhong Han,

Affiliations Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

http://orcid.org/0000-0001-8933-4637

⨯
Chao Tong,

Current address: Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, China

Affiliation Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
⨯
Bing Wang,

Affiliations Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
⨯
Yongbin Chen,

Affiliations Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
⨯
Jin Jiang

* E-mail: jin.jiang@utsouthwestern.edu

Affiliations Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
⨯

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase

Shuangxi Li,
Shuang Li,
Yuhong Han,
Chao Tong,
Bing Wang,
Yongbin Chen,
Jin Jiang

Published: June 9, 2016
https://doi.org/10.1371/journal.pbio.1002481

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Phosphorylation
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Hedgehog signaling
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Cloning
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Cell membranes
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Immunoprecipitation
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Transfection
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Cilia
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Immunostaining
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