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Open Access
Peer-reviewed
Research Article
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
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Yousuf O. Ali,
Affiliations Linda and Jack Gill Center, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America, The Cain Foundation Laboratories, Texas Children’s Hospital, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America
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Hunter M. Allen,
Affiliations Linda and Jack Gill Center, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America, The Cain Foundation Laboratories, Texas Children’s Hospital, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America
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Lei Yu,
Affiliation Rush Alzheimer’s Disease Center and Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America
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David Li-Kroeger,
Affiliations Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Dena Bakhshizadehmahmoudi,
Affiliations Linda and Jack Gill Center, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America, The Cain Foundation Laboratories, Texas Children’s Hospital, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America
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Asante Hatcher,
Affiliations The Cain Foundation Laboratories, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America
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Cristin McCabe,
Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
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Jishu Xu,
Affiliation Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
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Nicole Bjorklund,
Affiliation Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Giulio Taglialatela,
Affiliation Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
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David A. Bennett,
Affiliation Rush Alzheimer’s Disease Center and Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America
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Philip L. De Jager,
Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Joshua M. Shulman,
Affiliations Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America, Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
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Hugo J. Bellen,
Affiliations Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, Howard Hughes Medical Institute (HHMI), Baylor College of Medicine, Houston, Texas, United States of America
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Hui-Chen Lu
* E-mail: hclu@indiana.edu
Affiliations Linda and Jack Gill Center, Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America, The Cain Foundation Laboratories, Texas Children’s Hospital, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies
- Yousuf O. Ali,
- Hunter M. Allen,
- Lei Yu,
- David Li-Kroeger,
- Dena Bakhshizadehmahmoudi,
- Asante Hatcher,
- Cristin McCabe,
- Jishu Xu,
- Nicole Bjorklund,
- Giulio Taglialatela
- Published: June 2, 2016
- https://doi.org/10.1371/journal.pbio.1002472