Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO

Hande Boyaci; Tayyab Shah; Amanda Hurley; Bashkim Kokona; Zhijie Li; Christian Ventocilla; Philip D. Jeffrey; Martin F. Semmelhack; Robert Fairman; Bonnie L. Bassler; Frederick M. Hughson

doi:10.1371/journal.pbio.1002464

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Open Access

Peer-reviewed

Research Article

Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO

Hande Boyaci ,

Contributed equally to this work with: Hande Boyaci, Tayyab Shah

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Tayyab Shah ,

Contributed equally to this work with: Hande Boyaci, Tayyab Shah

Current address: Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut, United States of America

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Amanda Hurley,

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Bashkim Kokona,

Affiliation Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America

http://orcid.org/0000-0003-4264-8940

⨯
Zhijie Li,

Current address: Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina, United States of America

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Christian Ventocilla,

Current address: Hager Biosciences, Bethlehem, Pennsylvania, United States of America

Affiliation Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
⨯
Philip D. Jeffrey,

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Martin F. Semmelhack,

Affiliation Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
⨯
Robert Fairman,

Affiliation Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America
⨯
Bonnie L. Bassler,

Affiliations Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
Frederick M. Hughson

* E-mail: hughson@princeton.edu

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
⨯

Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO

Hande Boyaci,
Tayyab Shah,
Amanda Hurley,
Bashkim Kokona,
Zhijie Li,
Christian Ventocilla,
Philip D. Jeffrey,
Martin F. Semmelhack,
Robert Fairman,
Bonnie L. Bassler

Published: May 24, 2016
https://doi.org/10.1371/journal.pbio.1002464

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