Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

Guido Veit; Kathryn Oliver; Pirjo M. Apaja; Doranda Perdomo; Aurélien Bidaud-Meynard; Sheng-Ting Lin; Jingyu Guo; Mert Icyuz; Eric J. Sorscher; John L. Hartman IV; Gergely L. Lukacs

doi:10.1371/journal.pbio.1002462

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Open Access

Peer-reviewed

Research Article

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

Guido Veit,

Affiliation Department of Physiology, McGill University, Montréal, Quebec, Canada
⨯
Kathryn Oliver,

Affiliations Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Pirjo M. Apaja,

Affiliation Department of Physiology, McGill University, Montréal, Quebec, Canada
⨯
Doranda Perdomo,

Affiliation Department of Physiology, McGill University, Montréal, Quebec, Canada
⨯
Aurélien Bidaud-Meynard,

Affiliation Department of Physiology, McGill University, Montréal, Quebec, Canada
⨯
Sheng-Ting Lin,

Affiliation Department of Physiology, McGill University, Montréal, Quebec, Canada

http://orcid.org/0000-0002-8109-3557

⨯
Jingyu Guo,

Affiliation Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Mert Icyuz,

Affiliation Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Eric J. Sorscher,

Affiliation Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
John L. Hartman IV ,

* E-mail: jhartman@uab.edu (JLH); gergely.lukacs@mcgill.ca (GLL)

Affiliations Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Gergely L. Lukacs

* E-mail: jhartman@uab.edu (JLH); gergely.lukacs@mcgill.ca (GLL)

Affiliations Department of Physiology, McGill University, Montréal, Quebec, Canada, Department of Biochemistry, McGill University, Montréal, Quebec, Canada, Groupe de Recherche Axé sur la Structure des Protéines (GRASP), McGill University, Montréal, Quebec, Canada
⨯

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

Guido Veit,
Kathryn Oliver,
Pirjo M. Apaja,
Doranda Perdomo,
Aurélien Bidaud-Meynard,
Sheng-Ting Lin,
Jingyu Guo,
Mert Icyuz,
Eric J. Sorscher,
John L. Hartman IV

Published: May 11, 2016
https://doi.org/10.1371/journal.pbio.1002462

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