An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

Open Access

Peer-reviewed

Research Article

Paola Laurino,

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
⨯
Ágnes Tóth-Petróczy,

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
⨯
Rubén Meana-Pañeda,

Affiliation Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Wei Lin,

Affiliation Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Donald G. Truhlar,

Affiliation Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Dan S. Tawfik

* E-mail: dan.tawfik@weizmann.ac.il

Affiliation Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
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Ribose
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Biochemical cofactors
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Enzyme structure
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Protein folding
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Convergent evolution
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Methyltransferases
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Adenosine
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Protein structure
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