PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

Kai Jiang; Yajuan Liu; Junkai Fan; Jie Zhang; Xiang-An Li; B. Mark Evers; Haining Zhu; Jianhang Jia

doi:10.1371/journal.pbio.1002375

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Peer-reviewed

Research Article

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

Kai Jiang ,

Contributed equally to this work with: Kai Jiang, Yajuan Liu, Junkai Fan

Affiliation Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Yajuan Liu ,

Contributed equally to this work with: Kai Jiang, Yajuan Liu, Junkai Fan

Affiliation Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Junkai Fan ,

Contributed equally to this work with: Kai Jiang, Yajuan Liu, Junkai Fan

Current address: Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

Affiliation Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Jie Zhang,

Affiliation Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Xiang-An Li,

Affiliation Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
B. Mark Evers,

Affiliations Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Haining Zhu,

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Jianhang Jia

* E-mail: Jianhang.jia@uky.edu

Affiliations Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America, Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

Kai Jiang,
Yajuan Liu,
Junkai Fan,
Jie Zhang,
Xiang-An Li,
B. Mark Evers,
Haining Zhu,
Jianhang Jia

Published: February 10, 2016
https://doi.org/10.1371/journal.pbio.1002375

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Immunoprecipitation
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Phosphorylation
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Hedgehog signaling
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Transfection
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Lipids
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