mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination

Hong-Xia Wang; Jinwook Shin; Shang Wang; Balachandra Gorentla; Xingguang Lin; Jimin Gao; Yu-Rong Qiu; Xiao-Ping Zhong

doi:10.1371/journal.pbio.1002370

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Peer-reviewed

Research Article

mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination

Hong-Xia Wang,

Affiliations Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
⨯
Jinwook Shin,

Affiliation Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Shang Wang,

Affiliations Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Balachandra Gorentla,

Affiliation Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Xingguang Lin,

Affiliations Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Jimin Gao,

Affiliation School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Yu-Rong Qiu ,

* E-mail: xiaoping.zhong@duke.edu (XPZ); qiuyuronggz@126.com (YQ)

Affiliation Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
⨯
Xiao-Ping Zhong

* E-mail: xiaoping.zhong@duke.edu (XPZ); qiuyuronggz@126.com (YQ)

Affiliations Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America, Hematologic Malignancies and Cellular Therapies Program, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination

Hong-Xia Wang,
Jinwook Shin,
Shang Wang,
Balachandra Gorentla,
Xingguang Lin,
Jimin Gao,
Yu-Rong Qiu,
Xiao-Ping Zhong

Published: February 18, 2016
https://doi.org/10.1371/journal.pbio.1002370

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Cloning
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