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Open Access
Peer-reviewed
Research Article
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells
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David Gallego-Ortega ,
* E-mail: d.gallego@garvan.org.au (DGO); c.ormandy@garvan.org.au (CJO)
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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Anita Ledger,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Daniel L. Roden,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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Andrew M. K. Law,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Astrid Magenau,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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Zoya Kikhtyak,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Christina Cho,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Stephanie L. Allerdice,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Heather J. Lee,
Current address: Epigenetics ISP, Babraham Institute, Cambridge, United Kingdom
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Fatima Valdes-Mora,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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David Herrmann,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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Robert Salomon,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Adelaide I. J. Young,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Brian Y. Lee,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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C. Marcelo Sergio,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Warren Kaplan,
Affiliation Peter Wills Bioinformatic Center, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
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Catherine Piggin,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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James R. W. Conway,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Brian Rabinovich,
Affiliation The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
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Ewan K. A. Millar,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, Department of Anatomical Pathology SEALS, St. George Hospital, Kogarah, New South Wales, Australia, School of Medicine and Health Sciences, University of Western Sydney, Campbelltown, New South Wales, Australia
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Samantha R. Oakes,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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Tatyana Chtanova,
Affiliation Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia
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Alexander Swarbrick,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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Matthew J. Naylor,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, Sydney Medical School, University of Sydney, Camperdown, New South Wales, Australia
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Sandra O’Toole,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, Sydney Medical School, University of Sydney, Camperdown, New South Wales, Australia
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Andrew R. Green,
Affiliation Department of Histopathology, Nottingham City Hospital and Nottingham University, Nottingham, United Kingdom
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Paul Timpson,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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Julia M. W. Gee,
Affiliation Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom
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Ian O. Ellis,
Affiliation Department of Histopathology, Nottingham City Hospital and Nottingham University, Nottingham, United Kingdom
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Susan J. Clark,
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
⨯ - [ ... ],
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Christopher J. Ormandy
* E-mail: d.gallego@garvan.org.au (DGO); c.ormandy@garvan.org.au (CJO)
Affiliations Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia, St. Vincent’s Clinical School of Medicine, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia
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ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells
- David Gallego-Ortega,
- Anita Ledger,
- Daniel L. Roden,
- Andrew M. K. Law,
- Astrid Magenau,
- Zoya Kikhtyak,
- Christina Cho,
- Stephanie L. Allerdice,
- Heather J. Lee,
- Fatima Valdes-Mora
- Published: December 30, 2015
- https://doi.org/10.1371/journal.pbio.1002330