Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle

Open Access

Primers provide a concise introduction into an important aspect of biology highlighted by a current PLOS Biology research article.

Ruth Nussinov ,

* E-mail: NussinoR@helix.nih.gov

Affiliations Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America, Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
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Chung-Jung Tsai

Affiliations Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
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Allosteric regulation
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Cell binding
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Enzyme regulation
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Oncogenic signaling
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Protein domains
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Second messenger system
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Population dynamics
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Post-translational modification
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