Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

• Madoka Akimoto,

  Affiliation Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada

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• Eric Tyler McNicholl,

  Affiliation Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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• Avinash Ramkissoon,

  Affiliation Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada

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• Kody Moleschi,

  Affiliation Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada

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• Susan S. Taylor,

  Affiliation Department of Chemistry and Biochemistry, Department of Pharmacology and Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, United States of America

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• Giuseppe Melacini

  * E-mail: melacin@mcmaster.ca

  Affiliations Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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