Bistability in a Metabolic Network Underpins the De Novo Evolution of Colony Switching in Pseudomonas fluorescens

• Jenna Gallie ,

  * E-mail: jenna.gallie@gmail.com

  Affiliations New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand, Department of Environmental Microbiology, Eawag, Dübendorf, Switzerland, Department of Environmental Systems Science, ETH Zürich, Zürich, Switzerland

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• Eric Libby,

  Affiliations New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand, Santa Fe Institute, Santa Fe, New Mexico, United States of America

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• Frederic Bertels,

  Affiliations New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand, Institute of Integrative Biology, ETH Zürich, Zürich, Switzerland

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• Philippe Remigi,

  Affiliation New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand

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• Christian B. Jendresen,

  Affiliations Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark

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• Gayle C. Ferguson,

  Affiliation New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand

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• Nicolas Desprat,

  Affiliations Laboratoire de Physique Statistique (UMR8550), Ecole Normale Superieure, Paris, France, Institut de Biologie de l'ENS (IBENS UMR 8197), Ecole Normale Superieure, Paris, France, Universite Paris Diderot, Paris, France

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• Marieke F. Buffing,

  Affiliation Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland

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• Uwe Sauer,

  Affiliation Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland

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• Hubertus J. E. Beaumont,

  Affiliations New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand, Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands

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• Jan Martinussen,

  Affiliation Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

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• Mogens Kilstrup,

  Affiliation Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

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• Paul B. Rainey

  Affiliations New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand, Max-Planck Institute for Evolutionary Biology, Plön, Germany

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