Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages

Peter Sarkies; Murray E. Selkirk; John T. Jones; Vivian Blok; Thomas Boothby; Bob Goldstein; Ben Hanelt; Alex Ardila-Garcia; Naomi M. Fast; Phillip M. Schiffer; Christopher Kraus; Mark J. Taylor; Georgios Koutsovoulos; Mark L. Blaxter; Eric A. Miska

doi:10.1371/journal.pbio.1002061

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Open Access

Peer-reviewed

Research Article

Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages

Peter Sarkies ,

* E-mail: psarkies@imperial.ac.uk (PS); eam29@cam.ac.uk (EAM)

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
⨯
Murray E. Selkirk,

Affiliation Department of Life Sciences, Imperial College London, London, United Kingdom
⨯
John T. Jones,

Affiliation The James Hutton Institute, Invergowrie, Dundee, United Kingdom
⨯
Vivian Blok,

Affiliation The James Hutton Institute, Invergowrie, Dundee, United Kingdom
⨯
Thomas Boothby,

Affiliation Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Bob Goldstein,

Affiliation Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Ben Hanelt,

Affiliation Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, New Mexico, United States of America
⨯
Alex Ardila-Garcia,

Affiliation Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Naomi M. Fast,

Affiliation Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Phillip M. Schiffer,

Affiliation Zoologisches Institut, Universität zu Köln, Cologne, NRW, Germany
⨯
Christopher Kraus,

Affiliation Zoologisches Institut, Universität zu Köln, Cologne, NRW, Germany
⨯
Mark J. Taylor,

Affiliation Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Georgios Koutsovoulos,

Affiliation Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
⨯
Mark L. Blaxter,

Affiliation Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
⨯
Eric A. Miska

* E-mail: psarkies@imperial.ac.uk (PS); eam29@cam.ac.uk (EAM)

Affiliation Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, United Kingdom
⨯

Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages

Peter Sarkies,
Murray E. Selkirk,
John T. Jones,
Vivian Blok,
Thomas Boothby,
Bob Goldstein,
Ben Hanelt,
Alex Ardila-Garcia,
Naomi M. Fast,
Phillip M. Schiffer

Published: February 10, 2015
https://doi.org/10.1371/journal.pbio.1002061

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