Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

Kurt Vermeire; Thomas W. Bell; Victor Van Puyenbroeck; Anne Giraut; Sam Noppen; Sandra Liekens; Dominique Schols; Enno Hartmann; Kai-Uwe Kalies; Mark Marsh

doi:10.1371/journal.pbio.1002011

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Open Access

Peer-reviewed

Research Article

Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

Kurt Vermeire ,

* E-mail: kurt.vermeire@rega.kuleuven.be

Affiliations KU Leuven – University of Leuven, Department of Microbiology and Immunology, Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium, Institute of Biology, CSCM, University of Lübeck, Lübeck, Germany, MRC-Laboratory for Molecular Cell Biology, University College London, London, United Kingdom
⨯
Thomas W. Bell,

Affiliation Department of Chemistry, University of Nevada, Reno, Nevada, United States of America
⨯
Victor Van Puyenbroeck,

Affiliation KU Leuven – University of Leuven, Department of Microbiology and Immunology, Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
Anne Giraut,

Affiliation KU Leuven – University of Leuven, Department of Microbiology and Immunology, Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
Sam Noppen,

Affiliation KU Leuven – University of Leuven, Department of Microbiology and Immunology, Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
Sandra Liekens,

Affiliation KU Leuven – University of Leuven, Department of Microbiology and Immunology, Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
Dominique Schols,

Affiliation KU Leuven – University of Leuven, Department of Microbiology and Immunology, Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
⨯
Enno Hartmann,

Affiliation Institute of Biology, CSCM, University of Lübeck, Lübeck, Germany
⨯
Kai-Uwe Kalies ,

Contributed equally to this work with: Kai-Uwe Kalies, Mark Marsh

Affiliation Institute of Biology, CSCM, University of Lübeck, Lübeck, Germany
⨯
Mark Marsh

Contributed equally to this work with: Kai-Uwe Kalies, Mark Marsh

Affiliation MRC-Laboratory for Molecular Cell Biology, University College London, London, United Kingdom
⨯

Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

Kurt Vermeire,
Thomas W. Bell,
Victor Van Puyenbroeck,
Anne Giraut,
Sam Noppen,
Sandra Liekens,
Dominique Schols,
Enno Hartmann,
Kai-Uwe Kalies,
Mark Marsh

Published: December 2, 2014
https://doi.org/10.1371/journal.pbio.1002011

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