Carbonic Anhydrase Generates CO₂ and H⁺ That Drive Spider Silk Formation Via Opposite Effects on the Terminal Domains

• Marlene Andersson ,

  Contributed equally to this work with: Marlene Andersson, Gefei Chen

  Affiliation Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden

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• Gefei Chen ,

  Contributed equally to this work with: Marlene Andersson, Gefei Chen

  Affiliation Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, People's Republic of China

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• Martins Otikovs,

  Affiliation Department of Physical Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia

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• Michael Landreh,

  Affiliation Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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• Kerstin Nordling,

  Affiliation Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden

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• Nina Kronqvist,

  Affiliation Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden

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• Per Westermark,

  Affiliation Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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• Hans Jörnvall,

  Affiliation Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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• Stefan Knight,

  Affiliation Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden

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• Yvonne Ridderstråle,

  Affiliation Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden

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• Lena Holm,

  Affiliation Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden

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• Qing Meng ,

  * E-mail: janne.johansson@ki.se (J.J.); mengqing@dhu.edu.cn (Q.M.); anna.rising@ki.se (A.R.)

  Affiliation Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, People's Republic of China

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• Kristaps Jaudzems,

  Affiliation Department of Physical Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia

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• Mitchell Chesler,

  Affiliation Departments of Neurosurgery, Physiology and Neuroscience, New York University School of Medicine, New York, New York, United States of America

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• Jan Johansson ,

  * E-mail: janne.johansson@ki.se (J.J.); mengqing@dhu.edu.cn (Q.M.); anna.rising@ki.se (A.R.)

  ¶These authors also contributed equally to this work.

  Affiliations Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden, Institute of Mathematics and Natural Sciences, Tallinn University, Tallinn, Estonia

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•  [ ... ],
• Anna Rising

  * E-mail: janne.johansson@ki.se (J.J.); mengqing@dhu.edu.cn (Q.M.); anna.rising@ki.se (A.R.)

  ¶These authors also contributed equally to this work.

  Affiliations Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden

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