Discovery of a “White-Gray-Opaque” Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation

Li Tao; Han Du; Guobo Guan; Yu Dai; Clarissa J. Nobile; Weihong Liang; Chengjun Cao; Qiuyu Zhang; Jin Zhong; Guanghua Huang

doi:10.1371/journal.pbio.1001830

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Open Access

Peer-reviewed

Research Article

Discovery of a “White-Gray-Opaque” Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation

Li Tao ,

Contributed equally to this work with: Li Tao, Han Du

Affiliation State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Han Du ,

Contributed equally to this work with: Li Tao, Han Du

Affiliation State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Guobo Guan,

Affiliation State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Yu Dai,

Affiliation State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Clarissa J. Nobile,

Affiliation Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, California, United States of America
⨯
Weihong Liang,

Affiliations State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Chengjun Cao,

Affiliations State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Qiuyu Zhang,

Affiliations State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Jin Zhong,

Affiliation State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯
Guanghua Huang

* E-mail: huanggh@im.ac.cn

Affiliation State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⨯

Discovery of a “White-Gray-Opaque” Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation

Li Tao,
Han Du,
Guobo Guan,
Yu Dai,
Clarissa J. Nobile,
Weihong Liang,
Chengjun Cao,
Qiuyu Zhang,
Jin Zhong,
Guanghua Huang

Published: April 1, 2014
https://doi.org/10.1371/journal.pbio.1001830

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