Metabolic Erosion Primarily Through Mutation Accumulation, and Not Tradeoffs, Drives Limited Evolution of Substrate Specificity in Escherichia coli

Open Access

Peer-reviewed

Research Article

Nicholas Leiby,

Affiliations Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, Systems Biology Graduate Program, Harvard University, Cambridge, Massachusetts, United States of America
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Christopher J. Marx

* E-mail: cmarx@uidaho.edu

Current address: Biological Sciences, University of Idaho, Moscow, Idaho, United States of America

Affiliations Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America
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Glucose metabolism
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Glucose
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Substitution mutation
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Evolutionary adaptation
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Mutant strains
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Chi square tests
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Enzyme metabolism
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Escherichia coli
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