Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

• Austin Pantel ,

  Contributed equally to this work with: Austin Pantel, Angela Teixeira

  Affiliation Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America

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• Angela Teixeira ,

  Contributed equally to this work with: Austin Pantel, Angela Teixeira

  Affiliation Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America

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• Elias Haddad,

  Affiliation Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America

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• Elizabeth G. Wood,

  Affiliation William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom

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• Ralph M. Steinman †,

  † Deceased.

  ¶RMS and MPL also contributed equally to this work.

  Affiliation Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America

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• M. Paula Longhi

  * E-mail: m.longhi@qmul.ac.uk

  ¶RMS and MPL also contributed equally to this work.

  Affiliations Laboratory of Cellular Physiology and Immunology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, New York, United States of America, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom

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