Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

Thomas L. Rodgers; Philip D. Townsend; David Burnell; Matthew L. Jones; Shane A. Richards; Tom C. B. McLeish; Ehmke Pohl; Mark R. Wilson; Martin J. Cann

doi:10.1371/journal.pbio.1001651

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Open Access

Peer-reviewed

Research Article

Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

Thomas L. Rodgers ,

Contributed equally to this work with: Thomas L. Rodgers, Philip D. Townsend

Affiliations Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom
⨯
Philip D. Townsend ,

Contributed equally to this work with: Thomas L. Rodgers, Philip D. Townsend

Affiliations Biophysical Sciences Institute, Durham University, Durham, United Kingdom, School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom
⨯
David Burnell,

Affiliations Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom
⨯
Matthew L. Jones,

Affiliation Department of Physics, Durham University, Durham, United Kingdom
⨯
Shane A. Richards,

Affiliation School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom
⨯
Tom C. B. McLeish,

Affiliations Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom, Department of Physics, Durham University, Durham, United Kingdom
⨯
Ehmke Pohl,

Affiliations Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom, School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom
⨯
Mark R. Wilson,

Affiliations Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom
⨯
Martin J. Cann

* E-mail: m.j.cann@durham.ac.uk

Affiliations Biophysical Sciences Institute, Durham University, Durham, United Kingdom, School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom
⨯

Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

Thomas L. Rodgers,
Philip D. Townsend,
David Burnell,
Matthew L. Jones,
Shane A. Richards,
Tom C. B. McLeish,
Ehmke Pohl,
Mark R. Wilson,
Martin J. Cann

Published: September 10, 2013
https://doi.org/10.1371/journal.pbio.1001651

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