A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

Open Access

Peer-reviewed

Research Article

Stuart P. McElroy ,

* E-mail: s.mcelroy@dundee.ac.uk

Affiliation Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, James Black Centre, Dow Street, University of Dundee, Dundee, United Kingdom
⨯
Toshifumi Nomura,

Affiliation Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⨯
Leah S. Torrie,

Affiliation Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, James Black Centre, Dow Street, University of Dundee, Dundee, United Kingdom
⨯
Emma Warbrick,

Affiliation Division of Molecular Medicine, College of Life Sciences, Medical Sciences Institute, Dow Street, University of Dundee, Dundee, United Kingdom
⨯
Ulrike Gartner,

Affiliation Division of Molecular Medicine, College of Life Sciences, Medical Sciences Institute, Dow Street, University of Dundee, Dundee, United Kingdom
⨯
Gavin Wood,

Affiliation Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, James Black Centre, Dow Street, University of Dundee, Dundee, United Kingdom
⨯
W. H. Irwin McLean

Affiliation Division of Molecular Medicine, College of Life Sciences, Medical Sciences Institute, Dow Street, University of Dundee, Dundee, United Kingdom
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Transfection
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Nonsense mutation
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Collagens
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Transient transfection assay
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Insertion mutation
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Luciferase
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Site-directed mutagenesis
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