PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance

• Birgitte Holst ,

  Contributed equally to this work with: Birgitte Holst, Kenneth L. Madsen

  * E-mail: holst@sund.ku.dk (BH); okjaerulff@sund.ku.dk (OK); gether@sund.ku.dk (UG)

  Affiliations Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Kenneth L. Madsen ,

  Contributed equally to this work with: Birgitte Holst, Kenneth L. Madsen

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Anna M. Jansen,

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Chunyu Jin,

  Affiliations Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Mattias Rickhag,

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Viktor K. Lund,

  Affiliation Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Morten Jensen,

  Affiliations Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Vikram Bhatia,

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, BioNano Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Gunnar Sørensen,

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Andreas N. Madsen,

  Affiliations Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Zhichao Xue,

  Affiliations Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Siri K. Møller,

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• David Woldbye,

  Affiliation Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Klaus Qvortrup,

  Affiliation Core Facility for Integrated Microscopy, Department of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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• Richard Huganir,

  Affiliation Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Dimitrios Stamou,

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, BioNano Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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• Ole Kjærulff ,

  * E-mail: holst@sund.ku.dk (BH); okjaerulff@sund.ku.dk (OK); gether@sund.ku.dk (UG)

  Affiliation Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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•  [ ... ],
• Ulrik Gether

  * E-mail: holst@sund.ku.dk (BH); okjaerulff@sund.ku.dk (OK); gether@sund.ku.dk (UG)

  Affiliations Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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