PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

Mian Cao; Zhuo Mao; Chuen Kam; Nan Xiao; Xiaoxing Cao; Chong Shen; Kenneth K. Y. Cheng; Aimin Xu; Kwong-Man Lee; Liwen Jiang; Jun Xia

doi:10.1371/journal.pbio.1001541

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Open Access

Peer-reviewed

Research Article

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

Mian Cao ,

Contributed equally to this work with: Mian Cao, Zhuo Mao

Current address: Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

Affiliation Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
⨯
Zhuo Mao ,

Contributed equally to this work with: Mian Cao, Zhuo Mao

Affiliation Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
⨯
Chuen Kam,

Affiliation Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
⨯
Nan Xiao,

Affiliation Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
⨯
Xiaoxing Cao,

Affiliation Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
⨯
Chong Shen,

Affiliation Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
⨯
Kenneth K. Y. Cheng,

Affiliation Department of Medicine and Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, China
⨯
Aimin Xu,

Affiliation Department of Medicine and Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, China
⨯
Kwong-Man Lee,

Affiliation Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
⨯
Liwen Jiang,

Affiliation School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China
⨯
Jun Xia

* E-mail: jxia@ust.hk

Affiliation Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
⨯

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

Mian Cao,
Zhuo Mao,
Chuen Kam,
Nan Xiao,
Xiaoxing Cao,
Chong Shen,
Kenneth K. Y. Cheng,
Aimin Xu,
Kwong-Man Lee,
Liwen Jiang

Published: April 23, 2013
https://doi.org/10.1371/journal.pbio.1001541

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Insulin
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Insulin secretion
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Secretory granules
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