Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Roza Selimyan; Rachel M. Gerstein; Irina Ivanova; Patricia Precht; Ramesh Subrahmanyam; Thomas Perlot; Frederick W. Alt; Ranjan Sen

doi:10.1371/journal.pbio.1001475

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Peer-reviewed

Research Article

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Roza Selimyan,

Affiliation Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Rachel M. Gerstein,

Affiliation Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Irina Ivanova,

Affiliation Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Patricia Precht,

Affiliation Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Ramesh Subrahmanyam,

Affiliation Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Thomas Perlot,

Current address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria

Affiliation The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Frederick W. Alt,

Affiliation The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ranjan Sen

* E-mail: senranja@grc.nia.nih.gov

Affiliation Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Roza Selimyan,
Rachel M. Gerstein,
Irina Ivanova,
Patricia Precht,
Ramesh Subrahmanyam,
Thomas Perlot,
Frederick W. Alt,
Ranjan Sen

Published: January 29, 2013
https://doi.org/10.1371/journal.pbio.1001475

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DNA recombination
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