The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes

Estienne C. Swart; John R. Bracht; Vincent Magrini; Patrick Minx; Xiao Chen; Yi Zhou; Jaspreet S. Khurana; Aaron D. Goldman; Mariusz Nowacki; Klaas Schotanus; Seolkyoung Jung; Robert S. Fulton; Amy Ly; Sean McGrath; Kevin Haub; Jessica L. Wiggins; Donna Storton; John C. Matese; Lance Parsons; Wei-Jen Chang; Michael S. Bowen; Nicholas A. Stover; Thomas A. Jones; Sean R. Eddy; Glenn A. Herrick; Thomas G. Doak; Richard K. Wilson; Elaine R. Mardis; Laura F. Landweber

doi:10.1371/journal.pbio.1001473

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Research Article

The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes

Estienne C. Swart,

Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
John R. Bracht,

Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Vincent Magrini,

Affiliations The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Patrick Minx,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Xiao Chen,

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Yi Zhou,

Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Jaspreet S. Khurana,

Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Aaron D. Goldman,

Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Mariusz Nowacki,

Affiliations Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America, Institute of Cell Biology, University of Bern, Bern, Switzerland
⨯
Klaas Schotanus,

Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
Seolkyoung Jung,

Affiliation Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America
⨯
Robert S. Fulton,

Affiliations The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Amy Ly,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Sean McGrath,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kevin Haub,

Affiliation The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jessica L. Wiggins,

Affiliation Sequencing Core Facility, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯
Donna Storton,

Affiliation Sequencing Core Facility, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯
John C. Matese,

Affiliation Sequencing Core Facility, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯
Lance Parsons,

Affiliation Bioinformatics Group, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
⨯
Wei-Jen Chang,

Affiliation Department of Biology, Hamilton College, Clinton, New York, United States of America
⨯
Michael S. Bowen,

Affiliation Biology Department, Bradley University, Peoria, Illinois, United States of America
⨯
Nicholas A. Stover,

Affiliation Biology Department, Bradley University, Peoria, Illinois, United States of America
⨯
Thomas A. Jones,

Affiliation Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America
⨯
Sean R. Eddy,

Affiliation Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America
⨯
Glenn A. Herrick,

Affiliation Biology Department, University of Utah, Salt Lake City, Utah, United States of America
⨯
Thomas G. Doak,

Affiliation Department of Biology, University of Indiana, Bloomington, Indiana, United States of America
⨯
Richard K. Wilson,

Affiliations The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Elaine R. Mardis,

Affiliations The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
[ ... ],
Laura F. Landweber

* E-mail: lfl@princeton.edu

Affiliation Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
⨯
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The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with 16,000 Tiny Chromosomes

Estienne C. Swart,
John R. Bracht,
Vincent Magrini,
Patrick Minx,
Xiao Chen,
Yi Zhou,
Jaspreet S. Khurana,
Aaron D. Goldman,
Mariusz Nowacki,
Klaas Schotanus

Published: January 29, 2013
https://doi.org/10.1371/journal.pbio.1001473

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01 Apr 2015
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