Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication

• Karin Voordeckers ,

  Contributed equally to this work with: Karin Voordeckers, Chris A. Brown

  Affiliations VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

  ⨯
• Chris A. Brown ,

  Contributed equally to this work with: Karin Voordeckers, Chris A. Brown

  Affiliations VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium, Fathom Information Design, Boston, Massachusetts, United States of America, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

  ⨯
• Kevin Vanneste,

  Affiliations VIB Department of Plant Systems Biology, Gent, Belgium, Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium

  ⨯
• Elisa van der Zande,

  Affiliations VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

  ⨯
• Arnout Voet,

  Affiliation Laboratory for Molecular en Structural Biology, KU Leuven, Leuven, Belgium

  ⨯
• Steven Maere ,

  * E-mail: Steven.Maere@psb.vib-ugent.be (SM); Kevin.Verstrepen@biw.vib-kuleuven.be (KJV)

  Affiliations VIB Department of Plant Systems Biology, Gent, Belgium, Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium

  ⨯
• Kevin J. Verstrepen

  * E-mail: Steven.Maere@psb.vib-ugent.be (SM); Kevin.Verstrepen@biw.vib-kuleuven.be (KJV)

  Affiliations VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

  ⨯