Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

Gila Arad; Revital Levy; Iris Nasie; Dalia Hillman; Ziv Rotfogel; Uri Barash; Emmanuelle Supper; Tomer Shpilka; Adi Minis; Raymond Kaempfer

doi:10.1371/journal.pbio.1001149

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Open Access

Peer-reviewed

Research Article

Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

Gila Arad ,

Contributed equally to this work with: Gila Arad, Revital Levy

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Revital Levy ,

Contributed equally to this work with: Gila Arad, Revital Levy

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Iris Nasie,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Dalia Hillman,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Ziv Rotfogel,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Uri Barash,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Emmanuelle Supper,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Tomer Shpilka,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Adi Minis,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯
Raymond Kaempfer

* E-mail: kaempfer@hebrew.edu

Affiliation Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel
⨯

Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock

Gila Arad,
Revital Levy,
Iris Nasie,
Dalia Hillman,
Ziv Rotfogel,
Uri Barash,
Emmanuelle Supper,
Tomer Shpilka,
Adi Minis,
Raymond Kaempfer

Published: September 13, 2011
https://doi.org/10.1371/journal.pbio.1001149

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CD coreceptors
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