Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

Mathieu Blanc; Wei Yuan Hsieh; Kevin A. Robertson; Steven Watterson; Guanghou Shui; Paul Lacaze; Mizanur Khondoker; Paul Dickinson; Garwin Sing; Sara Rodríguez-Martín; Peter Phelan; Thorsten Forster; Birgit Strobl; Matthias Müller; Rudolph Riemersma; Timothy Osborne; Markus R. Wenk; Ana Angulo; Peter Ghazal

doi:10.1371/journal.pbio.1000598

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Peer-reviewed

Research Article

Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

Mathieu Blanc,

Affiliation Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
⨯
Wei Yuan Hsieh,

Affiliation Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
⨯
Kevin A. Robertson,

Affiliations Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom
⨯
Steven Watterson,

Affiliations Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom
⨯
Guanghou Shui,

Affiliation Department of Biochemistry and Department of Biological Sciences, National University of Singapore, Singapore
⨯
Paul Lacaze,

Affiliation Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
⨯
Mizanur Khondoker,

Affiliation Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
⨯
Paul Dickinson,

Affiliations Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom
⨯
Garwin Sing,

Affiliation Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
⨯
Sara Rodríguez-Martín,

Affiliation Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
⨯
Peter Phelan,

Affiliation Metabolic Signaling Diseases Program, Sanford-Burnham Medical Research Institute, Orlando, Florida, United States of America
⨯
Thorsten Forster,

Affiliations Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom
⨯
Birgit Strobl,

Affiliation Institute of Animal Breeding and Genetics, Veterinary University of Vienna, Vienna, Austria
⨯
Matthias Müller,

Affiliation Institute of Animal Breeding and Genetics, Veterinary University of Vienna, Vienna, Austria
⨯
Rudolph Riemersma,

Affiliation Centre for Cardiovascular Disease, University of Edinburgh, Edinburgh, United Kingdom
⨯
Timothy Osborne,

Affiliation Metabolic Signaling Diseases Program, Sanford-Burnham Medical Research Institute, Orlando, Florida, United States of America
⨯
Markus R. Wenk,

Affiliation Department of Biochemistry and Department of Biological Sciences, National University of Singapore, Singapore
⨯
Ana Angulo,

Affiliation Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
⨯
[ ... ],
Peter Ghazal

* E-mail: p.ghazal@ed.ac.uk

Affiliations Division of Pathway Medicine and Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom, Centre for Systems Biology at Edinburgh, The King's Buildings, Edinburgh, United Kingdom
⨯
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Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

Mathieu Blanc,
Wei Yuan Hsieh,
Kevin A. Robertson,
Steven Watterson,
Guanghou Shui,
Paul Lacaze,
Mizanur Khondoker,
Paul Dickinson,
Garwin Sing,
Sara Rodríguez-Martín

Published: March 8, 2011
https://doi.org/10.1371/journal.pbio.1000598

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29 Mar 2011
20:48 GMT
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Might lipid apheresis positively affect viral infection? Posted by damfotbol on 29 Mar 2011 at 20:48 GMT

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