High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

• Tsuyoshi Hirota,

  Affiliations Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Jae Wook Lee,

  Affiliations Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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• Warren G. Lewis,

  Affiliations Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Eric E. Zhang,

  Affiliations Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Ghislain Breton,

  Affiliation Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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• Xianzhong Liu,

  Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Michael Garcia,

  Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Eric C. Peters,

  Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Jean-Pierre Etchegaray,

  Affiliation Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• David Traver,

  Affiliation Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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• Peter G. Schultz,

  Affiliations Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America, Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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• Steve A. Kay

  * E-mail: skay@ucsd.edu

  Affiliation Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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