Protein Evolution by Molecular Tinkering: Diversification of the Nuclear Receptor Superfamily from a Ligand-Dependent Ancestor

Open Access

Peer-reviewed

Research Article

Jamie T. Bridgham,

Affiliations Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America
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Geeta N. Eick,

Affiliation Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America
⨯
Claire Larroux,

Current address: Department of Earth & Environmental Sciences, Ludwig-Maximilians-University, Munich, Germany

Affiliation School of Biological Sciences, University of Queensland, Brisbane, Australia
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Kirti Deshpande,

Affiliation Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America
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Michael J. Harms,

Affiliation Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America
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Marie E. A. Gauthier,

Affiliation School of Biological Sciences, University of Queensland, Brisbane, Australia
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Eric A. Ortlund,

Affiliation Biochemistry Department, Emory University School of Medicine, Atlanta, Georgia, United States of America
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Bernard M. Degnan,

Affiliation School of Biological Sciences, University of Queensland, Brisbane, Australia
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Joseph W. Thornton

* E-mail: joet@uoregon.edu

Affiliations Howard Hughes Medical Institute, Eugene, Oregon, United States of America, Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon, United States of America
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Phylogenetics
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Animal phylogenetics
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Phylogenetic analysis
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Crystal structure
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Sequence alignment
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Fatty acids
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Multiple alignment calculation
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Molecular evolution
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