TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species

• Andrea Kirmaier,

  Affiliations New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts, United States of America, Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

  ⨯
• Fan Wu,

  Affiliation Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Ruchi M. Newman,

  Affiliation Genome Sequencing and Analysis Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  ⨯
• Laura R. Hall,

  Affiliation New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts, United States of America

  ⨯
• Jennifer S. Morgan,

  Affiliation New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts, United States of America

  ⨯
• Shelby O'Connor,

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Preston A. Marx,

  Affiliation Tulane Regional Primate Research Center, Covington, Louisiana, United States of America

  ⨯
• Mareike Meythaler,

  Affiliations Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, New England Primate Research Center, Division of Immunology, Harvard Medical School, Southborough, Massachusetts, United States of America

  ⨯
• Simoy Goldstein,

  Affiliation Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Alicia Buckler-White,

  Affiliation Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Amitinder Kaur,

  Affiliation New England Primate Research Center, Division of Immunology, Harvard Medical School, Southborough, Massachusetts, United States of America

  ⨯
• Vanessa M. Hirsch,

  Affiliation Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Welkin E. Johnson

  * E-mail: wjohnson@hms.harvard.edu

  Affiliation New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts, United States of America

  ⨯