Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification

Stein Aerts; Xiao-Jiang Quan; Annelies Claeys; Marina Naval Sanchez; Phillip Tate; Jiekun Yan; Bassem A. Hassan

doi:10.1371/journal.pbio.1000435

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Peer-reviewed

Research Article

Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification

Stein Aerts ,

* E-mail: stein.aerts@med.kuleuven.be (SA); bassem.hassan@cme.vib-kuleuven.be (BAH)

Affiliations Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Laboratory of Computational Biology, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium, Doctoral Program in Molecular and Developmental Genetics, K.U. Leuven Group Biomedicine, Leuven, Belgium
⨯
Xiao-Jiang Quan,

Affiliations Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium
⨯
Annelies Claeys,

Affiliations Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium
⨯
Marina Naval Sanchez,

Affiliations Laboratory of Computational Biology, Katholieke Universiteit (K.U.) Leuven, Leuven, Belgium, Doctoral Program in Molecular and Developmental Genetics, K.U. Leuven Group Biomedicine, Leuven, Belgium
⨯
Phillip Tate,

Affiliations Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium
⨯
Jiekun Yan,

Affiliations Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium
⨯
Bassem A. Hassan

* E-mail: stein.aerts@med.kuleuven.be (SA); bassem.hassan@cme.vib-kuleuven.be (BAH)

Affiliations Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium, Center for Human Genetics, K.U. Leuven, Leuven, Belgium, Doctoral Program in Molecular and Developmental Genetics, K.U. Leuven Group Biomedicine, Leuven, Belgium
⨯

Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification

Stein Aerts,
Xiao-Jiang Quan,
Annelies Claeys,
Marina Naval Sanchez,
Phillip Tate,
Jiekun Yan,
Bassem A. Hassan

Published: July 27, 2010
https://doi.org/10.1371/journal.pbio.1000435

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Sequence motif analysis
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Drosophila melanogaster
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Gene expression
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Sensory perception
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Invertebrate genomics
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Introns
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Gene prediction
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