Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

Eric Dessaud; Vanessa Ribes; Nikolaos Balaskas; Lin Lin Yang; Alessandra Pierani; Anna Kicheva; Bennett G. Novitch; James Briscoe; Noriaki Sasai

doi:10.1371/journal.pbio.1000382

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Open Access

Peer-reviewed

Research Article

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

Eric Dessaud ,

Contributed equally to this work with: Eric Dessaud, Noriaki Sasai

Affiliation Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom
⨯
Vanessa Ribes,

Affiliation Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom
⨯
Nikolaos Balaskas,

Affiliation Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom
⨯
Lin Lin Yang,

Affiliation Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
⨯
Alessandra Pierani,

Affiliation Institut Jacques Monod, Université Paris Diderot, Program of Development and Neurobiology, Paris, France
⨯
Anna Kicheva,

Affiliation Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom
⨯
Bennett G. Novitch,

Affiliation Department of Neurobiology, Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
⨯
James Briscoe ,

* E-mail: james.briscoe@nimr.mrc.ac.uk

Affiliation Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom
⨯
Noriaki Sasai

Contributed equally to this work with: Eric Dessaud, Noriaki Sasai

Affiliation Developmental Neurobiology, MRC-National Institute for Medical Research, London, United Kingdom
⨯

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

Eric Dessaud,
Vanessa Ribes,
Nikolaos Balaskas,
Lin Lin Yang,
Alessandra Pierani,
Anna Kicheva,
Bennett G. Novitch,
James Briscoe,
Noriaki Sasai

Published: June 1, 2010
https://doi.org/10.1371/journal.pbio.1000382

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03 Jun 2010
04:22 GMT
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Morphogens
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Neurons
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Hedgehog signaling
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Gene expression
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Signal transduction
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DPP signaling cascade
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Embryonic pattern formation
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