A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G₂/M DNA Damage Checkpoint

• Marcel A. T. M. van Vugt,

  Current address: Department of Medical Oncology, University Medical Centre Groningen, Groningen, The Netherlands

  Affiliation David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Alexandra K. Gardino ,

  Contributed equally to this work with: Alexandra K. Gardino, Rune Linding, Gerard J. Ostheimer

  Affiliation David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Rune Linding ,

  Contributed equally to this work with: Alexandra K. Gardino, Rune Linding, Gerard J. Ostheimer

  Affiliation Cellular and Molecular Logic Team Integrative Network Biology initiative (INBi) Section of Cell and Molecular Biology, The Institute of Cancer Research, London, United Kingdom

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• Gerard J. Ostheimer ,

  Contributed equally to this work with: Alexandra K. Gardino, Rune Linding, Gerard J. Ostheimer

  Affiliations David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• H. Christian Reinhardt,

  Current address: University Hospital Cologne Department of Internal Medicine, Division I, Hematology/Oncology, and Max-Planck Institute, Cologne, Germany

  Affiliation David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Shao-En Ong,

  Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Chris S. Tan,

  Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

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• Hua Miao,

  Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Susan M. Keezer,

  Affiliation Cell Signaling Technologies, Danvers, Massachusetts, United States of America

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• Jeijin Li,

  Affiliation Division of Molecular Structure, Medical Research Council (MRC) National Institute for Medical Research, London, United Kingdom

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• Tony Pawson,

  Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Timothy A. Lewis,

  Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Steven A. Carr,

  Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Stephen J. Smerdon,

  Affiliation Division of Molecular Structure, Medical Research Council (MRC) National Institute for Medical Research, London, United Kingdom

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• Thijn R. Brummelkamp,

  Affiliation Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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•  [ ... ],
• Michael B. Yaffe

  * E-mail: myaffe@mit.edu

  Affiliations David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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