Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

Debora Bogani; Pam Siggers; Rachel Brixey; Nick Warr; Sarah Beddow; Jessica Edwards; Debbie Williams; Dagmar Wilhelm; Peter Koopman; Richard A. Flavell; Hongbo Chi; Harry Ostrer; Sara Wells; Michael Cheeseman; Andy Greenfield

doi:10.1371/journal.pbio.1000196

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Peer-reviewed

Research Article

Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

Debora Bogani,

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Pam Siggers,

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Rachel Brixey,

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Nick Warr,

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Sarah Beddow,

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Jessica Edwards,

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Debbie Williams,

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Dagmar Wilhelm,

Affiliation The Institute of Molecular Bioscience, University of Queensland, Brisbane, Australia
⨯
Peter Koopman,

Affiliation The Institute of Molecular Bioscience, University of Queensland, Brisbane, Australia
⨯
Richard A. Flavell,

Affiliation Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Hongbo Chi,

Affiliation Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Harry Ostrer,

Affiliation Human Genetics Program, New York University School of Medicine, New York, New York, United States of America
⨯
Sara Wells,

Affiliation The Mary Lyon Centre, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Michael Cheeseman,

Affiliations Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom, The Mary Lyon Centre, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯
Andy Greenfield

* E-mail: a.greenfield@har.mrc.ac.uk

Affiliation Mammalian Genetics Unit, Medical Research Council (MRC) Harwell, Oxfordshire, United Kingdom
⨯

Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

Debora Bogani,
Pam Siggers,
Rachel Brixey,
Nick Warr,
Sarah Beddow,
Jessica Edwards,
Debbie Williams,
Dagmar Wilhelm,
Peter Koopman,
Richard A. Flavell

Published: September 15, 2009
https://doi.org/10.1371/journal.pbio.1000196

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Gonads
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MAPK signaling cascades
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