The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay

• Niels H. Gehring ,

  * E-mail: Niels.Gehring@med.uni-heidelberg.de (NHG); Andreas.Kulozik@med.uni-heidelberg.de (AEK)

  Affiliations Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

  ⨯
• Styliani Lamprinaki,

  Affiliations Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

  ⨯
• Matthias W. Hentze,

  Affiliations Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, European Molecular Biology Laboratory, Heidelberg, Germany

  ⨯
• Andreas E. Kulozik

  * E-mail: Niels.Gehring@med.uni-heidelberg.de (NHG); Andreas.Kulozik@med.uni-heidelberg.de (AEK)

  Affiliations Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

  ⨯