The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions

• Cedric Montanier ,

  Contributed equally to this work with: Cedric Montanier, Victoria A Money

  Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

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• Victoria A Money ,

  Contributed equally to this work with: Cedric Montanier, Victoria A Money

  Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

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• Virginia M. R Pires,

  Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

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• James E Flint,

  Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

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• Benedita A Pinheiro,

  Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

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• Arun Goyal,

  Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

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• José A. M Prates,

  Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

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• Atsushi Izumi,

  Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

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• Henrik Stålbrand,

  Affiliation Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden

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• Carl Morland,

  Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

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• Alan Cartmell,

  Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

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• Katarina Kolenova,

  Affiliation Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden

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• Evangelos Topakas,

  Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

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• Eleanor J Dodson,

  Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

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• David N Bolam,

  Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

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• Gideon J Davies ,

  *To whom correspondence should be addressed. E-mail: davies@ysbl.york.ac.uk (GJD); H.J.Gilbert@ncl.ac.uk (HJG)

  Affiliation York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, United Kingdom

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• Carlos M. G. A Fontes,

  Affiliation CIISA - Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Avenida da Universidade Técnica, Lisboa, Portugal

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•  [ ... ],
• Harry J Gilbert

  *To whom correspondence should be addressed. E-mail: davies@ysbl.york.ac.uk (GJD); H.J.Gilbert@ncl.ac.uk (HJG)

  Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Newcastle upon Tyne, United Kingdom

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