A Point Mutation in the Hair Cell Nicotinic Cholinergic Receptor Prolongs Cochlear Inhibition and Enhances Noise Protection

• Julian Taranda,

  Affiliations Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina , Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Stéphane F Maison,

  Affiliation Department of Otology and Laryngology, Harvard Medical School and Eaton–Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

  ⨯
• Jimena A Ballestero,

  Affiliation Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

  ⨯
• Eleonora Katz,

  Affiliation Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

  ⨯
• Jessica Savino,

  Affiliation Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

  ⨯
• Douglas E Vetter,

  Affiliation Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Jim Boulter,

  Affiliation Department of Psychiatry and Biobehavioral Sciences, Hatos Research Center for Neuropharmacology, Brain Research and Molecular Biology Institutes, University of California, Los Angeles, United States of America

  ⨯
• M. Charles Liberman,

  Affiliation Department of Otology and Laryngology, Harvard Medical School and Eaton–Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America

  ⨯
• Paul A Fuchs,

  Affiliation Department of Otolaryngology, Head and Neck Surgery, and Center for Hearing and Balance, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• A. Belén Elgoyhen

  *To whom correspondence should be addressed. E-mail: elgoyhen@dna.uba.ar

  Affiliations Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina , Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

  ⨯