Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean-Philippe Coppé; Christopher K Patil; Francis Rodier; Yu Sun; Denise P Muñoz; Joshua Goldstein; Peter S Nelson; Pierre-Yves Desprez; Judith Campisi

doi:10.1371/journal.pbio.0060301

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Research Article

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean-Philippe Coppé,

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Christopher K Patil ,

Contributed equally to this work with: Christopher K Patil, Francis Rodier

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Francis Rodier ,

Contributed equally to this work with: Christopher K Patil, Francis Rodier

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America
⨯
Yu Sun,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Denise P Muñoz,

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America
⨯
Joshua Goldstein,

¤ Current address: Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
⨯
Peter S Nelson,

Affiliation Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Pierre-Yves Desprez,

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, California Pacific Medical Center Research Institute, San Francisco, California, United States of America
⨯
Judith Campisi

*To whom correspondence should be addressed. E-mail: jcampisi@lbl.gov

Affiliations Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Buck Institute for Age Research, Novato, California, United States of America
⨯

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean-Philippe Coppé,
Christopher K Patil,
Francis Rodier,
Yu Sun,
Denise P Muñoz,
Joshua Goldstein,
Peter S Nelson,
Pierre-Yves Desprez,
Judith Campisi

Published: December 2, 2008
https://doi.org/10.1371/journal.pbio.0060301

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11 Oct 2013
09:59 GMT
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