Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Stuart M Chambers; Chad A Shaw; Catherine Gatza; C. Joseph Fisk; Lawrence A Donehower; Margaret A Goodell

doi:10.1371/journal.pbio.0050201

Loading metrics

Open Access

Peer-reviewed

Research Article

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Stuart M Chambers,

Affiliations Program for Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America , Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Chad A Shaw,

Affiliations Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Catherine Gatza,

Affiliations Program for Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America , Department of Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
C. Joseph Fisk,

Affiliation Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Lawrence A Donehower,

Affiliations Program for Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America , Department of Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Margaret A Goodell

*To whom correspondence should be addressed. E-mail: goodell@bcm.edu

Affiliations Program for Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America , Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Stuart M Chambers,
Chad A Shaw,
Catherine Gatza,
C. Joseph Fisk,
Lawrence A Donehower,
Margaret A Goodell

Published: July 24, 2007
https://doi.org/10.1371/journal.pbio.0050201

Reader Comments (1)

Post a new comment on this article

0 Responses

26 Jan 2015
11:01 GMT
Most Recent

Removal of Previous Comments Posted by PLOSBiology on 26 Jan 2015 at 11:01 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hematopoietic stem cells
Is the Subject Area "Hematopoietic stem cells" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Aging
Is the Subject Area "Aging" applicable to this article?

Thanks for your feedback.
Gene ontologies
Is the Subject Area "Gene ontologies" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.
Aging and cancer
Is the Subject Area "Aging and cancer" applicable to this article?

Thanks for your feedback.
Chromatin
Is the Subject Area "Chromatin" applicable to this article?

Thanks for your feedback.