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Open Access
Peer-reviewed
Research Article
Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence
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João F Passos,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Gabriele Saretzki,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Shaheda Ahmed,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Glyn Nelson,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Torsten Richter,
Affiliation Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Heiko Peters,
Affiliation Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Ilka Wappler,
Affiliation Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Matthew J Birket,
Affiliation School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Graham Harold,
Affiliation Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Karin Schaeuble,
Affiliation Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Mark A Birch-Machin,
Affiliation School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Thomas B. L Kirkwood,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Thomas von Zglinicki
*To whom correspondence should be addressed. E-mail: t.vonzglinicki@ncl.ac.uk
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom , Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence
- João F Passos,
- Gabriele Saretzki,
- Shaheda Ahmed,
- Glyn Nelson,
- Torsten Richter,
- Heiko Peters,
- Ilka Wappler,
- Matthew J Birket,
- Graham Harold,
- Karin Schaeuble
- Published: May 1, 2007
- https://doi.org/10.1371/journal.pbio.0050110