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Open Access
Peer-reviewed
Research Article
Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence
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João F Passos,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Gabriele Saretzki,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Shaheda Ahmed,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Glyn Nelson,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Torsten Richter,
Affiliation Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Heiko Peters,
Affiliation Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Ilka Wappler,
Affiliation Institute of Human Genetics, International Centre for Life, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Matthew J Birket,
Affiliation School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Graham Harold,
Affiliation Crucible Laboratory, Life Knowledge Park, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Karin Schaeuble,
Affiliation Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Mark A Birch-Machin,
Affiliation School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Thomas B. L Kirkwood,
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Thomas von Zglinicki
*To whom correspondence should be addressed. E-mail: t.vonzglinicki@ncl.ac.uk
Affiliations Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom, Center for Integrated Systems Biology of Ageing and Nutrition, University of Newcastle, Newcastle upon Tyne, United Kingdom
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Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence
- João F Passos,
- Gabriele Saretzki,
- Shaheda Ahmed,
- Glyn Nelson,
- Torsten Richter,
- Heiko Peters,
- Ilka Wappler,
- Matthew J Birket,
- Graham Harold,
- Karin Schaeuble
- Published: May 1, 2007
- https://doi.org/10.1371/journal.pbio.0050110