Arkadia Enhances Nodal/TGF-β Signaling by Coupling Phospho-Smad2/3 Activity and Turnover

Konstantinos J Mavrakis; Rebecca L Andrew; Kian Leong Lee; Chariklia Petropoulou; James E Dixon; Naveenan Navaratnam; Dominic P Norris; Vasso Episkopou

doi:10.1371/journal.pbio.0050067

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Research Article

Arkadia Enhances Nodal/TGF-β Signaling by Coupling Phospho-Smad2/3 Activity and Turnover

Konstantinos J Mavrakis ,

Contributed equally to this work with: Konstantinos J Mavrakis, Rebecca L Andrew

Affiliation Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Rebecca L Andrew ,

Contributed equally to this work with: Konstantinos J Mavrakis, Rebecca L Andrew

Affiliation Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Kian Leong Lee,

Affiliation Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Chariklia Petropoulou,

Affiliation Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
James E Dixon,

Affiliation Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Naveenan Navaratnam,

Affiliation Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Dominic P Norris,

Affiliation Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom
⨯
Vasso Episkopou

*To whom correspondence should be addressed. E-mail: vepiskop@csc.mrc.ac.uk

Affiliation Mammalian Neurogenesis, Medical Research Council, Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯

Arkadia Enhances Nodal/TGF-β Signaling by Coupling Phospho-Smad2/3 Activity and Turnover

Konstantinos J Mavrakis,
Rebecca L Andrew,
Kian Leong Lee,
Chariklia Petropoulou,
James E Dixon,
Naveenan Navaratnam,
Dominic P Norris,
Vasso Episkopou

Published: March 6, 2007
https://doi.org/10.1371/journal.pbio.0050067

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