Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis

• Orion D Weiner ,

  Contributed equally to this work with: Orion D Weiner, Maike C Rentel

  Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Cardivascular Research Institute, University of California San Francisco, California, United States of America

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• Maike C Rentel ,

  Contributed equally to this work with: Orion D Weiner, Maike C Rentel

  Affiliation Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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• Alex Ott,

  Affiliation Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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• Glenn E Brown,

  Affiliation Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Mark Jedrychowski,

  Affiliation Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, Massachusetts, United States of America

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• Michael B Yaffe,

  Affiliation Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Steven P Gygi,

  Affiliation Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, Massachusetts, United States of America

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• Lewis C Cantley,

  Affiliation Department of Systems Biology, Harvard Medical School, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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• Henry R Bourne ,

  *To whom correspondence should be addressed. E-mail: bourne@cmp.ucsf.edu (HB), Email: marc@hms.harvard.edu (MK)

  Affiliation Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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• Marc W Kirschner

  *To whom correspondence should be addressed. E-mail: bourne@cmp.ucsf.edu (HB), Email: marc@hms.harvard.edu (MK)

  Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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