Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

• Laura Bordone ,

  *To whom correspondence should be addressed. E-mail: laura.bordone@novartis.com (LB); E-mail: leng@mit.edu (LG)

  ¤ Current address: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Maria Carla Motta ,

  Contributed equally to this work with: Maria Carla Motta, Frederic Picard, Ashley Robinson

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Frederic Picard ,

  Contributed equally to this work with: Maria Carla Motta, Frederic Picard, Ashley Robinson

  Affiliation Laval Hospital Research Center, Québec City, Québec, Canada

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• Ashley Robinson ,

  Contributed equally to this work with: Maria Carla Motta, Frederic Picard, Ashley Robinson

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Ulupi S Jhala,

  Affiliation The Whittier Institute for Diabetes, University of California San Diego, La Jolla, California, United States of America

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• Javier Apfeld,

  Affiliation Elixir Pharmaceuticals, Cambridge, Massachusetts, United States of America

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• Thomas McDonagh,

  Affiliation Elixir Pharmaceuticals, Cambridge, Massachusetts, United States of America

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• Madeleine Lemieux,

  Affiliation Department of Medicine and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, and the Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada

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• Michael McBurney,

  Affiliation Department of Medicine and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, and the Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada

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• Akos Szilvasi,

  Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

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• Erin J Easlon,

  Affiliation Center for Genetics and Development, and Section of Microbiology, University of California Davis, Davis, California, United States of America

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• Su-Ju Lin,

  Affiliation Center for Genetics and Development, and Section of Microbiology, University of California Davis, Davis, California, United States of America

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• Leonard Guarente

  *To whom correspondence should be addressed. E-mail: laura.bordone@novartis.com (LB); E-mail: leng@mit.edu (LG)

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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