Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses

Open Access

Peer-reviewed

Research Article

Grégoire Altan-Bonnet,

Affiliation Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
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Ronald N Germain

*To whom correspondence should be addressed. E-mail: rgermain@niaid.nih.gov

Affiliation Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America
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T cells
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TCR signaling cascade
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T cell receptors
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ERK signaling cascade
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Antigen-presenting cells
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MAPK signaling cascades
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Computer modeling
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Cell differentiation
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