Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase

Laura Cerchia; Frédéric Ducongé; Carine Pestourie; Jocelyne Boulay; Youssef Aissouni; Karine Gombert; Bertrand Tavitian; Vittorio de Franciscis; Domenico Libri

doi:10.1371/journal.pbio.0030123

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Open Access

Peer-reviewed

Research Article

Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase

Laura Cerchia ,

Contributed equally to this work with: Laura Cerchia, Frédéric Ducongé

Affiliation Istituto per I'Endocrinologia e Oncologia Molecolare “G. Salvatore”, CNR, Naples, Italy
⨯
Frédéric Ducongé ,

Contributed equally to this work with: Laura Cerchia, Frédéric Ducongé

Affiliation CEA/DSV/DRM Service Hospitalier Frédéric Joliot, INSERM E-103, Orsay, France
⨯
Carine Pestourie,

Affiliation CEA/DSV/DRM Service Hospitalier Frédéric Joliot, INSERM E-103, Orsay, France
⨯
Jocelyne Boulay,

Affiliation Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique (CNRS), Gif sur Yvette, France
⨯
Youssef Aissouni,

Affiliation Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique (CNRS), Gif sur Yvette, France
⨯
Karine Gombert,

Affiliation CEA/DSV/DRM Service Hospitalier Frédéric Joliot, INSERM E-103, Orsay, France
⨯
Bertrand Tavitian ,

*To whom correspondence should be addressed. E-mail: tavitian@shfj.cea.fr (BT), Email: defranci@unina.it (VD)

Affiliation CEA/DSV/DRM Service Hospitalier Frédéric Joliot, INSERM E-103, Orsay, France
⨯
Vittorio de Franciscis ,

*To whom correspondence should be addressed. E-mail: tavitian@shfj.cea.fr (BT), Email: defranci@unina.it (VD)

Affiliation Istituto per I'Endocrinologia e Oncologia Molecolare “G. Salvatore”, CNR, Naples, Italy
⨯
Domenico Libri

Affiliation Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique (CNRS), Gif sur Yvette, France
⨯

Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase

Laura Cerchia,
Frédéric Ducongé,
Carine Pestourie,
Jocelyne Boulay,
Youssef Aissouni,
Karine Gombert,
Bertrand Tavitian,
Vittorio de Franciscis,
Domenico Libri

Published: March 22, 2005
https://doi.org/10.1371/journal.pbio.0030123

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13 Mar 2014
16:31 GMT
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Concern about some of the figures Posted by libri on 13 Mar 2014 at 16:31 GMT

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Cell binding
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Tyrosine kinases
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Intracellular receptors
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Transmembrane receptors
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Cloning
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Dimers
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Point mutation
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Protein structure prediction
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