Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

Open Access

Peer-reviewed

Research Article

William G Fairbrother,

Affiliations Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Dirk Holste,

Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Christopher B Burge ,

*To whom correspondence should be addressed. E-mail: cburge@mit.edu (CB), Email: sharppa@mit.edu (PS)

Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Phillip A Sharp

*To whom correspondence should be addressed. E-mail: cburge@mit.edu (CB), Email: sharppa@mit.edu (PS)

Affiliations Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, McGovern Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Single nucleotide polymorphisms
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Point mutation
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Mutation
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Alleles
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Natural selection
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Human genomics
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Mutation databases
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Sequence alignment
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