Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion

Natalay Kouprina; Adam Pavlicek; Ganeshwaran H Mochida; Gregory Solomon; William Gersch; Young-Ho Yoon; Randall Collura; Maryellen Ruvolo; J. Carl Barrett; C. Geoffrey Woods; Christopher A Walsh; Jerzy Jurka; Vladimir Larionov

doi:10.1371/journal.pbio.0020126

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Open Access

Peer-reviewed

Research Article

Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion

Natalay Kouprina,

Affiliation Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Adam Pavlicek,

Affiliation Genetic Information Research Institute, Mountain View, California, United States of America
⨯
Ganeshwaran H Mochida,

Affiliation Department of Neurology, Howard Hughes Medical Institute and Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Gregory Solomon,

Affiliation Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
William Gersch,

Affiliation Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
Young-Ho Yoon,

Affiliation Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Randall Collura,

Affiliation Harvard University, Cambridge, Massachusetts, United States of America
⨯
Maryellen Ruvolo,

Affiliation Harvard University, Cambridge, Massachusetts, United States of America
⨯
J. Carl Barrett,

Affiliation Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
C. Geoffrey Woods,

Affiliation St. James's University Hospital, Leeds, United Kingdom
⨯
Christopher A Walsh,

Affiliation Department of Neurology, Howard Hughes Medical Institute and Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Jerzy Jurka ,

*To whom correspondence should be addressed. E-mail: jurka@girinst.org (JJ), Email: larionov@mail.nih.gov (VL)

Affiliation Genetic Information Research Institute, Mountain View, California, United States of America
⨯
Vladimir Larionov

*To whom correspondence should be addressed. E-mail: jurka@girinst.org (JJ), Email: larionov@mail.nih.gov (VL)

Affiliation Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, United States of America
⨯

Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion

Natalay Kouprina,
Adam Pavlicek,
Ganeshwaran H Mochida,
Gregory Solomon,
William Gersch,
Young-Ho Yoon,
Randall Collura,
Maryellen Ruvolo,
J. Carl Barrett,
C. Geoffrey Woods

Published: March 23, 2004
https://doi.org/10.1371/journal.pbio.0020126

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