Hello,
I find your article very interesting and I'm trying to understand it more in detail. I would like in particular to reproduce the model and analysis for Figure 5 ("Distinc combinatios of progenitor lineages..."). I have read the version in biorxiv and the version here, but I still can't figure out exactly how to do it.

Where could I find a more detailed explanation of each of the 7 lineage models?

The first 3 are pretty straighforward, but I'm a bit stuck with the others (4-7). Lineage 1 is just producing 1 additional neurone per cycle; lineage 2 produces 2 neurones/cycle; lineage 3 produces a new basal progenitor, each of which produce a new neurone/cycle.

Problems begin with lineage 4: each apical progenitor produces one basal progenitor, each of which produces a p-bIP which becomes 2 n-bIP, which become 4 neurones. So, why the output is not just 4 times the output of lineage 3?

I don't understand the diagram for lineage 5 either, in particular because there seem to be different types of bRG: a first type that divides into 2 new bRGs, another bRG that doesn't produce anything (one of the daughters of the 1st one), and another that goes through self-renewing... it's rather confusing... At the end, however, the lineage produces 4 neurones, just like lineage 4. Why are the equations not the same?

I have the same problems with lineages 6 and 7, where some cell types sometimes divide in one way, and sometimes in another. If I were to code the different lineages, wouldn't it be more clear to have different (unique) names for each cell type? Is there somewhere a more detailed explanation of the derivation of the formulas for the output of each lineage?

Thank you for the great work and thank you in advance for your help!