About the Authors

Hiroyuki J. Kanaya

Contributed equally to this work with: Hiroyuki J. Kanaya, Ken Kuwajima

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Ken Kuwajima

Contributed equally to this work with: Hiroyuki J. Kanaya, Ken Kuwajima

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation

Current address: Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Yuko Ito

Roles Investigation, Methodology, Resources

Affiliation Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan

Yuta Shinohara

Roles Funding acquisition, Investigation, Methodology, Resources

Current address: Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

Yohei Okubo

Roles Investigation, Methodology, Resources

Affiliation Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, Japan

Shinnosuke Shiono

Roles Methodology

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Fumiya Tatsuki

Roles Methodology

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Rei-ichiro Ohno

Roles Methodology, Resources

Affiliation Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Hideki Ukai

Roles Methodology, Resources

Current address: International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

Maki Ukai-Tadenuma

Roles Methodology, Resources

Current address: International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Affiliation Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

Kenta Sumiyama

Roles Methodology, Resources

Current address: Laboratory of Animal Genetics and Breeding, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Japan

Affiliation Laboratory for Mouse Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Suita, Osaka, Japan

Hiroshi Fujishima

Roles Methodology, Resources

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan, Department of Systems Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan

Rikuhiro G. Yamada

Roles Methodology, Resources

Affiliations Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan, Department of Systems Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan

Daisuke Tone

Roles Methodology, Resources

Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

Hiroshi Kiyonari

Roles Funding acquisition, Methodology, Resources

Affiliation Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Chuo-ku, Kobe, Japan

Masaki Kikuchi

Roles Investigation, Methodology

Current address: Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan

Affiliation Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Tsurumi, Yokohama, Japan

Takashi Umehara

Roles Investigation, Methodology

Current address: College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan

Affiliation Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Tsurumi, Yokohama, Japan

Takashi Murayama

Roles Funding acquisition, Methodology, Resources

Affiliation Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Tokyo, Japan

Kazunori Kanemaru

Roles Methodology, Resources

Affiliation Department of Physiology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

Masamitsu Iino

Roles Methodology, Resources

Affiliation Department of Physiology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

Koji L. Ode

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan

Takatsugu Hirokawa

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliations Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan, Division of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan

Hiroki R. Ueda

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

uedah-tky@umin.ac.jp

Affiliations Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Suita Osaka, Japan, Department of Systems Biology, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: HRU, KK, HJK, KLO, and TH have filed a patent application regarding the selective agonists of RyR1 that have sedative-like actions and anesthesia-assisting effects (by the University of Tokyo and University of Tsukuba, 2025-039456).