Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering

Shu-Ting You; Yu-Ting Jhou; Cheng-Fu Kao; Jun-Yi Leu

doi:10.1371/journal.pbio.3000433

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Open Access

Peer-reviewed

Research Article

Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering

Shu-Ting You,

Roles Formal analysis, Investigation, Validation, Writing – original draft

Affiliations Molecular and Cell Biology, Taiwan International Graduate Program, Graduate Institute of Life Sciences, National Defense Medical Center and Academia Sinica, Taipei, Taiwan, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

http://orcid.org/0000-0002-4581-9568

⨯
Yu-Ting Jhou,

Roles Investigation

Affiliation Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

http://orcid.org/0000-0001-7438-8069

⨯
Cheng-Fu Kao,

Roles Methodology

Affiliation Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
⨯
Jun-Yi Leu

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft

* E-mail: jleu@imb.sinica.edu.tw

Affiliations Molecular and Cell Biology, Taiwan International Graduate Program, Graduate Institute of Life Sciences, National Defense Medical Center and Academia Sinica, Taipei, Taiwan, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

http://orcid.org/0000-0001-5445-2799

⨯

Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering

Shu-Ting You,
Yu-Ting Jhou,
Cheng-Fu Kao,
Jun-Yi Leu

Published: October 15, 2019
https://doi.org/10.1371/journal.pbio.3000433
See the preprint

About the Authors

Shu-Ting You

Roles Formal analysis, Investigation, Validation, Writing – original draft

Affiliations Molecular and Cell Biology, Taiwan International Graduate Program, Graduate Institute of Life Sciences, National Defense Medical Center and Academia Sinica, Taipei, Taiwan, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

http://orcid.org/0000-0002-4581-9568

Yu-Ting Jhou

Roles Investigation

Affiliation Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

http://orcid.org/0000-0001-7438-8069

Cheng-Fu Kao

Roles Methodology

Affiliation Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan

Jun-Yi Leu

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft

* E-mail: jleu@imb.sinica.edu.tw

http://orcid.org/0000-0001-5445-2799

Competing Interests

The authors have declared that no competing interests exist.

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Green fluorescent protein
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Saccharomyces cerevisiae
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Fungal evolution
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Schizosaccharomyces pombe
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Yeast
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Methylation
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Methyltransferases
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Chromatin
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